dose stratum

personyears

cases

HR (95% CI)

p.value

atc_group: A01 (stomatological preparations)

no use

41,961,553

15,611

1.0 (ref)

>2 prescr.

3,532

0

4.6e-05 (1.1e-90-2e+81)

9.20e-01

25th percentile

164,415

103

1.2 (0.97-1.4)

9.30e-02

50th percentile

93,435

66

1.2 (0.97-1.6)

9.30e-02

75th percentile

49,585

42

1.4 (1-1.9)

3.80e-02

90th percentile

20,295

18

1.5 (0.93-2.3)

1.00e-01

atc_group: A02 (drugs for acid related disorders)

no use

35,906,365

12,136

1.0 (ref)

>2 prescr.

1,280,651

542

0.98 (0.89-1.1)

5.70e-01

25th percentile

2,185,808

1,265

1.2 (1.1-1.3)

1.50e-09

50th percentile

1,839,907

1,204

1.1 (1.1-1.2)

1.60e-04

75th percentile

819,954

529

0.96 (0.88-1.1)

4.20e-01

90th percentile

260,129

164

0.92 (0.79-1.1)

2.90e-01

atc_group: A03 (drugs for functional gastrointestinal disorders)

no use

41,289,868

15,256

1.0 (ref)

>2 prescr.

7,597

0

1.8e-05 (3.4e-102-9.4e+91)

9.20e-01

25th percentile

463,399

228

1.1 (0.95-1.2)

2.20e-01

50th percentile

283,205

175

1.3 (1.1-1.5)

4.40e-04

75th percentile

172,072

117

1.4 (1.1-1.6)

7.70e-04

90th percentile

76,673

64

1.7 (1.3-2.2)

3.20e-05

atc_group: A06 (drugs for constipation)

no use

41,746,574

15,218

1.0 (ref)

>2 prescr.

7,456

0

1.7e-05 (1.1e-94-2.6e+84)

9.20e-01

25th percentile

268,070

323

1.7 (1.5-1.9)

8.50e-20

50th percentile

141,029

187

1.8 (1.6-2.1)

3.70e-16

75th percentile

80,286

81

1.5 (1.2-1.8)

6.10e-04

90th percentile

49,399

31

1 (0.71-1.4)

9.20e-01

atc_group: A11 (vitamins)

no use

40,125,099

14,318

1.0 (ref)

>2 prescr.

583,103

333

1.3 (1.1-1.4)

5.40e-05

25th percentile

512,545

370

1.4 (1.2-1.5)

1.00e-09

50th percentile

632,256

528

1.3 (1.2-1.5)

4.00e-11

75th percentile

313,084

239

1 (0.92-1.2)

4.90e-01

90th percentile

126,728

52

0.56 (0.43-0.74)

3.80e-05

atc_group: A12 (mineral supplements)

no use

40,208,012

14,247

1.0 (ref)

>2 prescr.

540,251

389

1.2 (1.1-1.3)

4.10e-04

25th percentile

626,885

539

1.3 (1.2-1.4)

1.70e-10

50th percentile

545,576

427

1.1 (1-1.3)

7.30e-03

75th percentile

258,517

164

0.88 (0.76-1)

1.10e-01

90th percentile

113,573

74

0.93 (0.73-1.2)

5.10e-01

atc_group: B01 (antithrombotic agents)

no use

34,650,302

8,827

1.0 (ref)

>2 prescr.

2,129,634

1,860

1.3 (1.3-1.4)

5.00e-30

25th percentile

2,646,001

2,474

1.2 (1.2-1.3)

2.70e-15

50th percentile

2,062,564

2,009

1.1 (1.1-1.2)

3.80e-05

75th percentile

599,070

526

0.92 (0.84-1)

5.30e-02

90th percentile

205,244

144

0.83 (0.7-0.98)

2.50e-02

atc_group: B03 (antianemic preparations)

no use

39,710,443

14,126

1.0 (ref)

>2 prescr.

658,883

452

1.3 (1.2-1.4)

6.60e-08

25th percentile

857,919

616

1.3 (1.2-1.4)

8.20e-08

50th percentile

566,786

369

1.1 (0.97-1.2)

1.90e-01

75th percentile

332,957

190

0.91 (0.78-1)

1.80e-01

90th percentile

165,828

87

0.76 (0.62-0.94)

1.20e-02

atc_group: C01 (cardiac therapy)

no use

40,086,414

13,679

1.0 (ref)

>2 prescr.

464,666

420

1.2 (1.1-1.3)

8.70e-04

25th percentile

756,000

720

1.2 (1.1-1.3)

8.00e-05

50th percentile

588,008

642

1.2 (1.1-1.3)

3.20e-06

75th percentile

285,167

300

1.1 (1-1.3)

2.70e-02

90th percentile

112,560

79

0.84 (0.68-1.1)

1.30e-01

atc_group: C07 (beta blocking agents)

no use

36,167,406

10,486

1.0 (ref)

>2 prescr.

1,698,829

1,572

1.5 (1.4-1.6)

1.80e-54

25th percentile

2,132,260

1,876

1.2 (1.2-1.3)

3.50e-15

50th percentile

1,675,625

1,418

1 (0.99-1.1)

1.30e-01

75th percentile

470,849

405

0.97 (0.88-1.1)

5.30e-01

90th percentile

147,845

83

0.75 (0.6-0.93)

8.10e-03

atc_group: C09 (agents acting on the renin-angiotensin system)

no use

34,127,144

10,184

1.0 (ref)

>2 prescr.

2,748,962

1,853

1.1 (1-1.1)

4.90e-02

25th percentile

2,746,811

1,818

0.9 (0.86-0.95)

6.70e-05

50th percentile

1,917,893

1,431

0.87 (0.83-0.92)

2.70e-06

75th percentile

592,305

485

0.85 (0.78-0.93)

5.70e-04

90th percentile

159,701

69

0.49 (0.38-0.62)

2.40e-09

atc_group: D01 (antifungals for dermatological use)

no use

39,693,243

14,327

1.0 (ref)

>2 prescr.

10,924

0

1.6e-05 (2.2e-97-1.2e+87)

9.20e-01

25th percentile

1,267,365

696

1.2 (1.1-1.3)

4.20e-06

50th percentile

571,228

348

1.2 (1.1-1.4)

1.60e-04

75th percentile

535,040

342

1.2 (1.1-1.3)

1.90e-03

90th percentile

215,015

127

0.96 (0.81-1.1)

6.60e-01

atc_group: G03 (sex hormones and modulators of the genital system)

no use

34,253,116

13,673

1.0 (ref)

>2 prescr.

1,845,965

481

1.2 (1.1-1.3)

1.70e-03

25th percentile

2,908,602

743

1.2 (1.1-1.3)

2.40e-04

50th percentile

2,087,963

547

1 (0.95-1.1)

3.60e-01

75th percentile

896,099

286

1 (0.9-1.1)

8.20e-01

90th percentile

301,070

110

0.95 (0.78-1.1)

5.70e-01

atc_group: G04 (urologicals)

no use

38,702,552

11,885

1.0 (ref)

>2 prescr.

997,317

885

1.4 (1.3-1.5)

1.30e-17

25th percentile

979,236

1,131

1.6 (1.5-1.7)

7.70e-51

50th percentile

979,057

1,188

1.5 (1.4-1.6)

5.00e-41

75th percentile

449,466

551

1.4 (1.3-1.5)

1.90e-13

90th percentile

185,187

200

1.2 (1.1-1.4)

3.00e-03

atc_group: H01 (pituitary and hypothalamic hormones and analogues)

no use

41,932,195

15,742

1.0 (ref)

>2 prescr.

1,845

0

0.00012 (6e-123-2.3e+114)

9.50e-01

25th percentile

152,325

32

2.1 (1.5-3)

3.00e-05

50th percentile

137,791

30

1.9 (1.3-2.7)

6.60e-04

75th percentile

52,630

22

1.6 (1-2.4)

3.70e-02

90th percentile

16,029

14

1.5 (0.88-2.5)

1.40e-01

atc_group: H02 (corticosteroids for systemic use)

no use

38,533,637

14,039

1.0 (ref)

>2 prescr.

12,626

0

6e-06 (5e-120-7.1e+108)

9.30e-01

25th percentile

1,816,421

801

0.92 (0.85-0.98)

1.50e-02

50th percentile

1,104,438

557

0.92 (0.84-1)

5.30e-02

75th percentile

615,561

329

0.82 (0.73-0.91)

2.80e-04

90th percentile

210,131

114

0.72 (0.6-0.87)

4.90e-04

atc_group: J01 (antibacterials for systemic use)

no use

20,538,423

7,149

1.0 (ref)

>2 prescr.

5,732,343

2,157

0.98 (0.94-1)

4.80e-01

25th percentile

6,698,580

2,696

0.99 (0.95-1)

6.60e-01

50th percentile

5,507,217

2,161

0.89 (0.85-0.94)

6.50e-06

75th percentile

2,657,311

1,097

0.85 (0.8-0.91)

1.40e-06

90th percentile

1,158,940

580

0.89 (0.81-0.96)

5.50e-03

atc_group: L01 (antineoplastic agents)

no use

42,169,103

15,782

1.0 (ref)

>2 prescr.

1,740

0

4.5e-05 (1.5e-122-1.4e+113)

9.40e-01

25th percentile

53,352

24

0.56 (0.38-0.84)

5.00e-03

50th percentile

33,298

19

0.75 (0.48-1.2)

2.20e-01

75th percentile

20,841

9

0.6 (0.31-1.2)

1.30e-01

90th percentile

14,481

6

0.55 (0.24-1.2)

1.40e-01

atc_group: M01 (antiinflammatory and antirheumatic products)

no use

22,646,864

7,937

1.0 (ref)

>2 prescr.

4,844,955

1,652

1 (0.94-1)

8.60e-01

25th percentile

7,060,628

2,753

1.1 (1-1.1)

1.60e-03

50th percentile

4,130,258

1,762

1.1 (1-1.1)

6.40e-03

75th percentile

2,583,838

1,230

1 (0.98-1.1)

1.40e-01

90th percentile

1,026,271

506

0.93 (0.85-1)

1.30e-01

atc_group: M05 (drugs for treatment of bone diseases)

no use

41,147,195

14,797

1.0 (ref)

>2 prescr.

279,070

314

1.6 (1.5-1.8)

3.10e-17

25th percentile

326,083

315

1.4 (1.2-1.5)

6.80e-08

50th percentile

311,203

241

1 (0.92-1.2)

5.40e-01

75th percentile

167,692

139

1.1 (0.92-1.3)

3.50e-01

90th percentile

61,572

34

0.76 (0.54-1.1)

1.10e-01

atc_group: N02 (analgesics)

no use

28,053,325

9,094

1.0 (ref)

>2 prescr.

3,810,108

1,554

1.1 (1-1.1)

5.80e-02

25th percentile

4,355,738

2,114

1.2 (1.1-1.2)

3.10e-10

50th percentile

3,549,109

1,867

1.2 (1.1-1.3)

1.10e-11

75th percentile

2,001,974

1,010

1.1 (1-1.2)

9.80e-04

90th percentile

522,560

201

0.89 (0.77-1)

9.70e-02

atc_group: N03 (antiepileptics)

no use

40,365,777

14,656

1.0 (ref)

>2 prescr.

327,467

211

1.5 (1.3-1.7)

8.80e-09

25th percentile

605,775

405

1.6 (1.5-1.8)

7.20e-23

50th percentile

621,626

376

1.5 (1.3-1.7)

1.70e-14

75th percentile

284,974

156

1.3 (1.1-1.5)

2.70e-03

90th percentile

87,196

36

0.96 (0.69-1.3)

8.30e-01

atc_group: N05 (psycholeptics)

no use

31,695,517

9,374

1.0 (ref)

>2 prescr.

2,722,322

1,435

1.4 (1.3-1.5)

1.40e-33

25th percentile

3,265,296

2,108

1.5 (1.4-1.5)

1.20e-53

50th percentile

2,852,777

1,911

1.3 (1.3-1.4)

5.00e-31

75th percentile

1,303,642

793

1.3 (1.2-1.4)

4.50e-11

90th percentile

453,260

219

1.1 (0.97-1.3)

1.10e-01

atc_group: N06 (psychoanaleptics)

no use

36,045,124

11,733

1.0 (ref)

>2 prescr.

1,399,581

814

1.9 (1.8-2)

5.50e-69

25th percentile

2,115,503

1,510

2.3 (2.2-2.4)

6.40e-195

50th percentile

1,781,068

1,202

1.9 (1.8-2)

5.50e-93

75th percentile

725,177

457

1.5 (1.4-1.7)

2.40e-19

90th percentile

226,360

124

1.3 (1.1-1.5)

5.60e-03

atc_group: N07 (other nervous system drugs)

no use

41,273,429

15,620

1.0 (ref)

>2 prescr.

6,269

0

4.7e-05 (2.8e-108-7.7e+98)

9.30e-01

25th percentile

382,903

85

0.73 (0.59-0.91)

4.20e-03

50th percentile

407,404

85

0.67 (0.54-0.82)

1.80e-04

75th percentile

159,351

38

0.71 (0.52-0.98)

3.70e-02

90th percentile

63,458

12

0.95 (0.54-1.7)

8.70e-01

atc_group: R03 (drugs for obstructive airway diseases)

no use

36,976,015

13,589

1.0 (ref)

>2 prescr.

1,478,237

514

0.89 (0.82-0.98)

1.30e-02

25th percentile

1,569,100

675

0.96 (0.89-1)

3.40e-01

50th percentile

1,455,375

672

0.82 (0.76-0.89)

9.60e-07

75th percentile

604,046

301

0.76 (0.68-0.86)

3.50e-06

90th percentile

210,042

89

0.61 (0.49-0.75)

3.50e-06

atc_group: R05 (cough and cold preparations)

no use

34,148,841

12,149

1.0 (ref)

>2 prescr.

27,387

0

6.1e-06 (1.4e-97-2.6e+86)

9.10e-01

25th percentile

3,236,960

1,373

0.98 (0.93-1)

5.70e-01

50th percentile

3,237,747

1,458

0.93 (0.88-0.98)

1.20e-02

75th percentile

1,172,868

600

0.91 (0.84-0.99)

3.40e-02

90th percentile

469,012

260

0.86 (0.76-0.97)

1.40e-02

atc_group: S01 (ophthalmologicals)

no use

32,977,748

10,608

1.0 (ref)

>2 prescr.

18,364

0

6.6e-06 (1e-102-4.2e+91)

9.20e-01

25th percentile

4,576,507

2,276

1.1 (1.1-1.2)

4.50e-07

50th percentile

2,956,602

1,786

1.2 (1.2-1.3)

1.40e-16

75th percentile

1,423,283

941

1.1 (1-1.2)

3.50e-03

90th percentile

340,312

229

0.89 (0.78-1)

7.20e-02

atc_group: S03 (ophthalmological and otological preparations)

no use

40,965,577

15,291

1.0 (ref)

>2 prescr.

4,785

0

4.5e-05 (2e-90-1e+81)

9.20e-01

25th percentile

620,714

249

0.86 (0.76-0.97)

1.60e-02

50th percentile

409,045

170

0.83 (0.72-0.97)

1.80e-02

75th percentile

186,014

88

0.86 (0.69-1.1)

1.50e-01

90th percentile

106,679

42

0.65 (0.48-0.88)

5.90e-03